Mar 1, 2024 · We have synthesized eleven derivatives of 1,3-oxathio-2-imine, characterized through NMR, HREI-MS and evaluated against acetylcholinesterase and butyr…

In this study, a novel compound (1) has been synthesized by combination of flurbiprofen and isoniazide and shows ∼2.5 times enhanced acetylcholinesterase (AChE) inhibition activity and …

Pharmacophore-based virtual screening and molecular docking to identify promising dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

Both acetylcholinesterase and butylcholinesterase are selected as targets for the phytoconstituents to dock. The mechanism being cholinesterase enzyme acts on acetylcholine …

This guide outlines the key structural features of Convolvine and discusses the anticipated impact of structural modifications on its activity, based on the broader understanding of tropane …

Oct 25, 2025 · Benzimidazole analogues (1–15) were prepared and screened for in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition.

The objective of this research is to use in silico methodologies namely, pharmacophore-based virtual screening and molecular docking to find potential dual inhibitors targeting both hAChE …

Oct 1, 2015 · A series of thirty (30) thiazole analogs were prepared, characterized by 1H NMR, 13C NMR and EI-MS and evaluated for Acetylcholinesterase and butyrylc…

May 11, 2025 · The two main enzymes involved in ACh breakdown are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE is the primary enzyme regulating cholinergic …

Docking studies and density functional theory (DFT) calculations were made for 88 N-aryl derivatives and for some acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) …