It was 2012 when Love Dalén, a paleogeneticist at Stockholm University, first laid eyes upon a special specimen on a lab table in eastern Siberia. "Our Russian collaborators said, 'Come here into this ...

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...

If you want to be a dependable machine gunner, you'll want to eke the most performance out of your LMGs as possible. Tyler is a writer under CNET's home energy and utilities category. He came to CNET ...

If you’ve been playing Battlefield 6 over the launch weekend, you may have noticed that one of the more popular support weapons is not the beefcake LMGs we associate with the role. Instead, the LSW ...

The densities of RNA-seq reads (in reads per kilo-bases per million reads, RPKM) were normalized to the library size and the number of sites in 20bp sliding windows along the genome.

Optionally scaling can be turned off and individual samples normalized using the RPKM, BPM or CPM methods (or no normalization at all) But, also: --normalizeUsing Possible choices: RPKM, CPM, BPM, ...

What biological questions can single-molecule RNA sequencing help address that traditional methods cannot? How can these technologies be applied in your area of research, and what limitations might ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

Roche has put forward a new approach to genetic analysis, which it describes as sequencing-by-expansion—a proprietary method that pulls apart the DNA molecule and amplifies the signal of each ...

An individual’s genome is identifiable. But datasets of RNA sequences from single cells are like a blurry photocopy of the genome. The sequence numbers are small, the data are noisy, and the sequences ...