Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as well as transformation during cancer. Researchers led by Ikerbasque Research ...
One of the central components of the immune system is the enzyme cyclic GMP-AMP synthase (cGAS), which acts as a guard, detecting foreign DNA and initiating an immune response. If cGAS is not properly ...
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens, T cell ...
Researchers have developed intranasal spherical nucleic acids that activate the cGAS–STING pathway and reprogram the ...
Activating this signaling pathway, known as the cGAS-STING pathway, worked even better when combined with existing immunotherapy drugs known as checkpoint blockade inhibitors, in a study of mice. That ...
The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...
Company is evaluating IMSB301 in a Phase 1 clinical trial in healthy volunteers and plans to move rapidly into Phase 1b/2 clinical studies in patients with AGS, lupus and other cGAS-driven diseases ...
Researchers can use messenger RNA to trigger the immune system to attack tumors. By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, MIT (MA, ...
A glucose-sensitive nanovaccine delivers CRISPR to tumors, silences immune-suppressing genes, and activates a targeted immune response against cancer. (Nanowerk Spotlight) Immune-based cancer ...
Glioblastoma is the most common and deadliest brain cancer, killing about three in 100,000 people yearly. It grows quickly, resists treatment, and often returns after treated. Scientists have dubbed ...
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