The San Francisco 49ers could be getting some unexpected speed injected into their receiving corps late in the 2025 season.

The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.

The Tennessee Titans say the home of defensive tackle Jeffery Simmons was burglarized while he was on the road in San Francisco.

Despite the missed opportunity to gain ground, the 49ers improved to 10-4 and remain firmly in the playoff hunt with three games left on the schedule. San Francisco will travel to face the Indianapolis Colts in Week 16 before closing the regular season with home games against the Chicago Bears and the Seahawks.

It's clear the 49ers are relying on Pearsall to become Aiyuk's successor in the receiving corps — this season and in the future.

The San Francisco 49ers officially will face off against Philip Rivers in Week 16 against the Indianapolis Colts.

It helps when George Kittle, Jauan Jennings, and Ricky Pearsall all seem to be healthy and at their best. Still, there is no denying that Purdy was looking at his healthiest as well, and he was making plays just as much as anyone in this win.